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Leonard (Pearce) is an insurance investigator whose memory has been damaged following a head injury he sustained after intervening in his wife's murder.Subsequently, the quality of his life is severely hampered and he can now only live a comprehendible life of prolific note-taking, tattooing notes on himself and taking pictures of things with a Polaroid camera.
As his memories come to him, Leonard badly yearns for revenge of his wife's murder.But as numerous characters explain, there may be little point if he won't remember to enjoy his revenge.
Who are his friends?Who are his enemies?What is the truth?In Leonard's world, the answers to these questions shift and change from second to second.And the more he tries to figure out what is true and real, the deeper he sinks into a multi-layered abyss of uncertainty and surprises.